Role of Folic Acid and Energy Intake in Nucleic Acid Synthesis
نویسندگان
چکیده
منابع مشابه
Inhibition of nucleic acid synthesis by folic acid antagonists.
Woolley and Pringle (13) have recently reported the formation of 4-amino-5-carboxamidoimidazole during growth of Escherichia coli in the presence of 4-aminopteroylglutainic acid (aminopterin). Some of us have observed that excessive doses of folie acid speed up the leukemic process in mice and that folie acid will reverse the well known antileukemic action of aminopterin (11). This reversal of ...
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پس ازفروپاشی شوروی،رشد منابع نفت و گاز، آسیای میانه و قفقاز را در یک بازی ژئوپلتیکی انرژی قرار داده است. با در نظر گرفتن این منابع هیدروکربنی، این منطقه به یک میدانجنگ و رقابت تجاری برای بازی های ژئوپلتیکی قدرت های بزرگ جهانی تبدیل شده است. روسیه منطقه را به عنوان حیات خلوت خود تلقی نموده و علاقمند به حفظ حضورش می باشد تا همانند گذشته گاز طبیعی را به وسیله خط لوله مرکزی دریافت و به عنوان یک واس...
15 صفحه اولHigh intake of folic acid attenuates 6-hydroxydopamine-induced Parkinsonism
Introduction: High levels of homocysteine (Hcy) might accelerate dopaminergic cell death through oxidative stress and excitotoxicity. Folate plays an important role in the control of plasma levels of Hcy. In this study, effect of supplementation with folic acid on the 6-hydroxydopamine (6-OHDA)-induced Parkinsonism in rat and also serum level of Hcy was investigated. Methods: Rats were fed ...
متن کاملEffects of a folic acid antagonist on nucleic acid metabolism.
Microbiological evidence (1) first implicated folic acid in nucleic acid synthesis, and several lines of investigation suggest that citrovorum factor, or another derivative of folic acid, may function in some manner as a coenzyme in the metabolism of a l-carbon moiety. The function of the formy1 group in rhizopterin (2) and citrovorum factor (3) has not been clarified. The incorporation of form...
متن کاملThe effect of folic acid on A-methopterin-induced inhibition of nucleic acid synthesis.
It has been observed that folie acid (2) or citrovorum factor (1) will prevent the anti-leukemic ac tion of folie acid antagonists. We have reported that desoxyribonucleic acid (5) and vitamin Bi2 (7) will partially prevent the anti-leukemic action of 4-aminopteroylglutamic acids, and have more re cently observed that a combination of thymidine, adenylic, guanylic, and cytidylic acids or DNA pl...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)70258-5